Preparing Modified Hyaluronic Acid with Tunable Content of Vinyl Groups for Use in Fabrication of Scaffolds by Photoinduced Crosslinking

Abstract Materials based on hyaluronic acid (HA) are extensively used in tissue engineering as scaffolds. Photoinduced crosslinking is one way to prepare them, and, for this, HA must be modified with vinyl groups, which capable of participating free-radical reactions upon exposure light. The quantity grafted represented the degree substitution (DS), an important parameter (mHA) that related mechanical, chemical, and biological properties Here, we demonstrate feasibility tuning DS by varying reaction parameters (composition concentration components conditions) investigate effect viscosity mHA solutions. As example, consider photoinduced presence flavin mononucleotide initiator, can fabrication noncytotoxic scaffolds 3D printing. growth behavior fibroblasts scaffold surface studied.